解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The hippocampus receives robust serotonergic innervation that is thought to control the excitability of both pyramidal cells and GABAergic interneurons. Previous work has addressed serotonergic regulation of pyramidal cells but considerable gaps remain in our understanding of how serotonin regulates different interneu...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22611
更新日期:2016-09-01 00:00:00
abstract::The influence of the learning process on the persistence of the newly acquired behavior is relevant both for our knowledge of the learning/memory mechanisms and for the educational policy. However, it is unclear whether during an operant conditioning process with a continuous reinforcement paradigm, individual differe...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22568
更新日期:2016-07-01 00:00:00
abstract::The goal of the present research was to assess the degree to which a pattern completion process operates in cue-induced relapse to cocaine-seeking behavior. Using a novel cue-preference version of the place preference task, rats were administered cocaine or saline, which resulted in a preference for the cocaine-paired...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22570
更新日期:2016-07-01 00:00:00
abstract::Episodic memory improves during childhood and this improvement has been associated with age differences in hippocampal function, but previous research has not manipulated the possible underlying mechanisms. We tested the hypothesis that age-related differences in hippocampal activation may reflect changes in retrieval...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22538
更新日期:2016-04-01 00:00:00
abstract::Presenting stimuli again after presentation of intervening stimuli improves their retention, an effect known as the spacing effect. However, using event-related potentials (ERPs), we had observed that immediate, in comparison to spaced, repetition of pictures induced a positive frontal potential at 200-300 ms. This po...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22534
更新日期:2016-04-01 00:00:00
abstract::The survival of adult-born dentate gyrus granule cells critically depends on their synaptic integration into the existing neuronal network. Excitatory inputs are thought to increase the survival rate of adult born neurons. Therefore, whether enhancing the stability of newly formed excitatory synapses by overexpressing...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22524
更新日期:2016-03-01 00:00:00
abstract::A large body of neuroscientific work indicates that exposure to experienced stress causes damage to both cortical and hippocampal cells and results in impairments to cognitive abilities associated with these structures. Similarly, work within the domain of cognitive aging demonstrates that elderly participants who rep...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22525
更新日期:2016-03-01 00:00:00
abstract::There is limited knowledge regarding how the brain controls the timing of meals. Similarly, there is a large gap in our understanding of how top-down cognitive processes, such as memory influence energy intake. We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22532
更新日期:2016-03-01 00:00:00
abstract::Aging has been associated with a decline in relational memory, which is critically supported by the hippocampus. By adapting the transitivity paradigm (Bunsey and Eichenbaum (1996) Nature 379:255-257), which traditionally has been used in nonhuman animal research, this work examined the extent to which aging is accomp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22501
更新日期:2016-02-01 00:00:00
abstract::Adult neurogenesis in the dentate gyrus (DG) plays a crucial role for pattern separation, and there are sex differences in the regulation of neurogenesis. Although sex differences, favoring males, in spatial navigation have been reported, it is not known whether there are sex differences in pattern separation. The cur...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22493
更新日期:2016-01-01 00:00:00
abstract::It is well documented that place cells and grid cells in echolocating bats show properties similar to those described in rodents, and yet, continuous theta-frequency oscillations, proposed to play a central role in grid/place cell formation, are not present in bat recordings. These comparative neurophysiological data ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22469
更新日期:2015-12-01 00:00:00
abstract::In contextual fear conditioning (CFC), the use of pharmacological and lesion approaches has helped to understand that there are differential roles for the dorsal hippocampus (DH) and the ventral hippocampus (VH) in the acquisition, consolidation and retrieval phases. Concomitant analysis of the DH and the VH in indivi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22470
更新日期:2015-12-01 00:00:00
abstract::Anatomical and electrophysiological studies collectively suggest that the entorhinal cortex consists of several subregions, each of which is involved in the processing of different types of information. Consistent with this idea, we previously reported that the dorsolateral portion of the entorhinal cortex (DLE), but ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22466
更新日期:2015-11-01 00:00:00
abstract::A striking similarity has been suggested between past and future thinking in Alzheimer's Disease (AD), a similarity attributable to abnormalities in common modular cognitive functions and neuroanatomical substrates. This study extends this literature by identifying specific executive function deficits underlying past ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22465
更新日期:2015-11-01 00:00:00
abstract::This study investigates relationship between regional cerebral volumes and performances over time of a categorical fluency task, in a sample of older adults (n = 316). Using voxel-wise technique, the relationship between local grey matter volume and Isaacs Set Test (IST) scores at its early (first 15 sec) and late (la...
journal_title:Hippocampus
pub_type: 杂志文章,多中心研究
doi:10.1002/hipo.22423
更新日期:2015-09-01 00:00:00
abstract::People retain more new verbal episodic information for at least 7 days if they rest for a few minutes after learning than if they attend to new information. It is hypothesized that rest allows for superior consolidation of new memories. In rodents, rest periods promote hippocampal replay of a recently travelled route,...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22424
更新日期:2015-09-01 00:00:00
abstract::The hippocampus is essential for the consolidation of some explicit long-term memories, including trace conditioning. Lesions and pharmacological manipulations of the dorsal hippocampus (DH) have provided strong evidence for its involvement in the acquisition and expression of trace fear memories. However, no studies ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22413
更新日期:2015-07-01 00:00:00
abstract::Rett syndrome (RTT) is a neurodevelopment disorder associated with intellectual disabilities and caused by loss-of-function mutations in the gene encoding the transcriptional regulator Methyl-CpG-binding Protein-2 (MeCP2). Neuronal dysfunction and changes in cortical excitability occur in RTT individuals and Mecp2-def...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22360
更新日期:2015-02-01 00:00:00
abstract::Several recent studies have compared episodic and spatial memory in neuroimaging paradigms in order to understand better the contribution of the hippocampus to each of these tasks. In the present study, we build on previous findings showing common neural activation in default network areas during episodic and spatial ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22352
更新日期:2015-01-01 00:00:00
abstract::Hippocampal adult neurogenesis contributes to key functions of the dentate gyrus (DG), including contextual discrimination. This is due, at least in part, to the unique form of plasticity that new neurons display at a specific stage of their development when compared with the surrounding principal neurons. In addition...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22313
更新日期:2014-11-01 00:00:00
abstract::The multifactorial causes impacting the risk of developing sporadic forms of Alzheimer's disease (AD) remain to date poorly understood. Epidemiologic studies in humans and research in rodents have suggested that hypothyroidism could participate in the etiology of AD. Recently, we reported that adult-onset hypothyroidi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22319
更新日期:2014-11-01 00:00:00
abstract::The role of perforant pathway-dentate granule cell synapses in cognitive behavior was examined focusing on synaptic Zn(2+) signaling in the dentate gyrus. Object recognition memory was transiently impaired when extracellular Zn(2+) levels were decreased by injection of clioquinol and N,N,N',N'-tetrakis-(2-pyridylmethy...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22322
更新日期:2014-11-01 00:00:00
abstract::We often engage in counterfactual (CF) thinking, which involves reflecting on "what might have been." Creating alternative versions of reality seems to have parallels with recollecting the past and imagining the future in requiring the simulation of internally generated models of complex events. Given that episodic me...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22323
更新日期:2014-11-01 00:00:00
abstract::Human navigation studies show that landmarks are used for orientation, whereas objects contribute to the contextual representation of an environment. What constitutes a landmark? Classic rodent studies show that hippocampal place fields are controlled by distal, polarizing cues. Place fields, however, are also influen...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22331
更新日期:2014-11-01 00:00:00
abstract::The vestibular system contributes to the performance of various spatial memory tasks, but few studies have attempted to disambiguate the roles of the semicircular canals and otolith organs in this performance. This study tested the otolithic contribution to spatial working and reference memory by evaluating the perfor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22300
更新日期:2014-10-01 00:00:00
abstract::Thrombin and other clotting factors regulate long-term potentiation (LTP) in the hippocampus through the activation of the protease activated receptor 1 (PAR1) and consequent potentiation of N-methyl-d-aspartate receptor (NMDAR) functions. We have recently shown that the activation of PAR1 either by thrombin or the an...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22288
更新日期:2014-08-01 00:00:00
abstract::Although there are many types of epilepsy, temporal lobe epilepsy (TLE) is probably in humans the most common and most often studied. TLE represents 40% of the total epilepsy form of the disease and is difficult to treat. Despite a wealth of descriptive data obtained from the disease history of patients, the EEG recor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22246
更新日期:2014-06-01 00:00:00
abstract::The hippocampus creates distinct episodes from highly similar events through a process called pattern separation and can retrieve memories from partial or degraded cues through a process called pattern completion. These processes have been studied in humans using tasks where participants must distinguish studied items...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22256
更新日期:2014-06-01 00:00:00
abstract::Dorsoventral lesion studies of the hippocampus have indicated that the dorsal axis of the hippocampus is important for spatial processing and the ventral axis of the hippocampus is important for olfactory learning and memory and anxiety. There is some evidence to suggest that the ventral CA3 and ventral CA1 conduct pa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22248
更新日期:2014-05-01 00:00:00
abstract::Subjective and objective memory deficits represent a frequent and ill-understood aspect of multiple sclerosis (MS), and a significant cause of disability and quality of life reduction. The aim of the study is to verify the role of hippocampal and temporal associative fibers' damage in MS-related memory complaints. To ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22237
更新日期:2014-04-01 00:00:00
abstract::Wnt proteins have emerged as transmembrane signaling molecules that regulate learning and memory as well as synaptic plasticity at central synapses (Inestrosa and Arenas (2010) Nat Rev Neurosci 11:77-86; Maguschak and Ressler (2011) J Neurosci 31:13057-13067; Tabatadze et al. (2012) Hippocampus 22: 1228-1241; Fortress...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22239
更新日期:2014-04-01 00:00:00
abstract::It is well established that aging is associated with declines in episodic memory. In recent years, an emphasis has emerged on the development of behavioral tasks and the identification of biomarkers that are predictive of cognitive decline in healthy as well as pathological aging. Here, we describe a memory task desig...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22224
更新日期:2014-03-01 00:00:00
abstract::Neuronal oscillations and cross-frequency interactions in the rat hippocampus relate in important ways to memory processes and serve as a model for studying oscillatory activity in cognition more broadly. We report here that hippocampal synchrony (CA3-CA1 coherence) increased markedly in the low gamma range as rats we...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22228
更新日期:2014-03-01 00:00:00
abstract::GABAergic inhibitory interneurons control fundamental aspects of neuronal network function. Their functional roles are assumed to be defined by the identity of their input synapses, the architecture of their dendritic tree, the passive and active membrane properties and finally the nature of their postsynaptic targets...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22214
更新日期:2014-02-01 00:00:00
abstract::Neural correlates of spatial representation can be found in the activity of the hippocampal place cells. These neurons are characterized by firing whenever the animal is located in a particular area of the space, the place field. Place fields are modulated by sensory cues, such as visual, auditory, or olfactory cues, ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22198
更新日期:2013-12-01 00:00:00
abstract::The precise timing of pre-postsynaptic activity is vital for the induction of long-term potentiation (LTP) or depression (LTD) at many central synapses. We show in synapses of rat CA1 pyramidal neurons in vitro that spike timing dependent plasticity (STDP) protocols that induce LTP at glutamatergic synapses can evoke ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22196
更新日期:2013-12-01 00:00:00
abstract::Individuals with schizophrenia display a number of structural and cytoarchitectural alterations in the hippocampus, suggesting that other functions such as synaptic plasticity may also be modified. Altered hippocampal plasticity is likely to affect memory processing, and therefore any such pathology may contribute to ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22193
更新日期:2013-12-01 00:00:00
abstract::Learning and memory can be controlled by distinct memory systems. How these systems are coordinated to optimize learning and behavior has long been unclear. Accumulating evidence indicates that stress may modulate the engagement of multiple memory systems. In particular, rodent and human studies demonstrate that stres...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.22175
更新日期:2013-11-01 00:00:00
abstract::Spatial navigation relies on multiple mnemonic mechanisms and previous work in younger adults has described two separate types of spatial memory. One type uses directional as well as boundary-related information for spatial memory and mainly implicates the hippocampal formation. The other type has been linked to direc...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22148
更新日期:2013-10-01 00:00:00
abstract::The hippocampus is critical for memory tasks which require an active maintenance of memory for a short period of time; however, the underlying neural mechanisms remain unknown. Most theoretical and computational models, which date back to the classic proposals by Donald Hebb in , have been self-constrained by anatomy,...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22136
更新日期:2013-09-01 00:00:00